Stephanie Frappart will become the first woman to referee a major men's European match as she has been chosen to take chage of the UEFA Super Cup final between Liverpool and Chelsea, which will be held on 14 August.
Frappart will be aided by two female assistant referees as the UEFA Champions League winners take on the UEFA Europa League winners.
The 35-year-old Frenchwoman took charge of the Women's World Cup final which was held in July in Lyon.
Current UEFA president Aleksander Ceferin stated "I hope the skill and devotion that Stephanie has shown throughout her career to reach this level will provide inspiration to millions of girls and women around Europe, and show them there should be no barriers in order to reach one's dream."
The assistant referees for the match will be Manuela Nicolosi from France and Michelle O'Neill from the Republic of Ireland.
The officials will also be aided by male referee Cuneyt Cakir, who will be the fourth official. The Turkish referee took charge of the 2015 UEFA Champions League final.
Frappart became the first female referee to take charge of a Ligue 1 match in April, and in 2014 she was also the first female to take charge of a Ligue 2 match.