The 23-year-old centre-back was substituted on during injury-time to help United defend a 3-2 lead late on at Old Trafford, yet his foul on Josh King led to Everton's very late equaliser, as Dominic Calvert-Lewin capitalised on some shocking defending from United to score in the 95th minute.
This led to several racist messages on Instagram directed towards Tuanzebe, with this being the second time in ten days that the defender has suffered this form of abuse.
He had previously suffered this sort of abuse after a disappointing performance in United's 2-1 loss against Sheffield United over a week ago.
Speaking on the messages that Tuanzebe received after the game against the Blades, United manager Ole Gunnar Solskjaer said "It's just incredible we have these scenes still, this abuse in 2021."
"We've been campaigning for a long time now with the Premier League and I think it's working but there are still some people that haven't got it."
"They hide behind social media and be anonymous. It’s unacceptable and it’s disgusting. They’re not Man United fans when this happens. We’re all standing behind every single one of our players."
"Axel is fine, I’ve spoken to him, and of course it’s not nice but he’s a strong boy, strong character."
Some of the messages Tuanzebe received included the n-word and several monkey and gorilla emojis.
Manchester United campaigned even more against racism over the last few weeks, after Anthony Martial and Marcus Rashford, along with Tuanzebe, were also subject to such abuse.